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KMID : 1134820070360060670
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Journal of the Korean Society of Food Science and Nutrition
2007 Volume.36 No. 6 p.670 ~ p.677
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Antioxidant Activity and Physiological Function of the Anomala albopilosa Extracts
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Yoon Weon-Jong
Lee Jung-A
Kim Ji-Young
Kim Sang-Bum
Park Soo-Yeong
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Abstract
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We analyzed antioxidant and physiological activities to investigate the functional effects of ethanol extracts of Anomala albopilosa imago and A. albopilosa larva. In order to effectively screen for anti-inflammatory agents, we first investigated the antioxidant activities such as DPPH radical scavenging capacity, superoxide radical scavenging capacity, xanthine oxidase inhibitory activity, and nitric oxide scavenging capacity of the A. albopilosa extracts. By the screening system, we found that A. albopilosa extracts had antioxidant activity which increased with increments of the extract concentration. Moreover, we examined the inhibitory effect of the A. albopilosa extracts on the production of anti-inflammatory factors that the nitric oxide (NO), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and prostaglandin E₂(PGE₂) production activated with LPS (1 ㎍/mL) in murine macrophage cell line RAW 264.7. A. albopilosa extracts potentially inhibited the iNOS and COX-2 in a dose-dependent manner. The inhibition of iNOS activity was correlated with the decrease in nitrite levels. Additionally, the PEG2 production is markedly inhibited after a treatment with the A. albopilosa extracts.
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KEYWORD
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Anomala albopilosa, imago, larva, antioxidant activity, anti-inflammatory effects
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